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KMID : 0603820110170040363
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Journal of Experimental & Biomedical Science
2011 Volume.17 No. 4 p.363 ~ p.366
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Antibacterial Effect of Photodynamic Therapy using Photogem and a 632 ㎚ Diode Laser on Helicobacter pylori
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Ahn Jin-Chul
Shin Jang-In
Chang So-Young
Kim Hong-Ja
Hong Seong-No
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Abstract
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Eradication of H. pylori, usually carried out by using antimicrobial agents, is essential for preventing gastric ulcers and cancers. The H. pylori isolates, however, have continuously grown antimicrobial resistance, which have caused difficulty in treating the bacteria and in turn, photodynamic therapy (PDT) has been found to be effective in inducing deaths of variety of bacteria. After PDT treatment, the number of colony forming units (CFU), the morphologic changes, and flow cytometry were observed. In the PDT group containing 100 and 200 ㎍/㎖ photogem, no live H. pylori was observed, while 10 and 50 ㎍/㎖ photogem were only partially effective. H. pylori of the PDT group also displayed distortion and shrinkage in morphology. This study demonstrated that photogem-mediated PDT effectively induces deaths of H. pylori.
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KEYWORD
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Photodynamic therapy, Photogem, Helicobacter pylori
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